Florida State polished off 14th seed Little Rock 91-49, extending its streak of consecutive NCAA first-round victories to 15, dating back to 1991.
Mfiondu Kabengele scored 14 points, and Florida State beat No. 8 seed Missouri 67-54 on Friday night in the West Region.
Trent Forrest and P.J. Savoy each scored 14 points and Phil Cofer added 12 as the Seminoles flirted with some March magic before falling to the Louisville Cardinals, 82-74, here at the Barclays Center.
Fifth-ranked Florida State scored two runs in the first inning, the second of which proved to be the game-winner, en route to an 11-1 win over visiting Xavier to open the 2018 season.
The Seminoles shot under 32 percent from the floor in the second half and just 1 of 10 from beyond the arc as the Cavaliers held on for the 59-55 victory on Wednesday night.
Florida State made one of the biggest early moves, rising five spots Wednesday to No. 11 before dropping to No. 22 in late afternoon on Wednesday for National Signing Day.
Terance Mann delivered a timely block of VJ King's shot with 6 seconds remaining, Braian Angola grabbed the rebound and fed to M.J. Walker for a dunk with 1 second left that clinched the Seminoles' 80-76 win on Saturday.
AJ Alix made a go-ahead 3-pointer with 1:04 remaining and Nicki Ekhomu added a free throw with 7.8 seconds left, helping No. 12 Florida State hand No. 2 Louisville its first loss of the season, 50-49, Sunday.